Search for novel circulating cancer chemopreventive biomarkers of dietary rice bran intervention in Apc mice model of colorectal carcinogenesis, using proteomic and metabolic profiling strategies. Authors
نویسندگان
چکیده
Authors Leonie Norris, Aditya Malkar, Emma Horner-Glister, Amirmansoor Hakimi, Leong L Ng, Andreas J Gescher, Colin Creaser, Stewart Sale and Donald JL Jones. Addresses: Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, University of Leicester, Leicester. LE2 7LX. Centre for Analytical Science, Department of Chemistry, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK. Department of Cardiovascular Sciences and NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK.
منابع مشابه
The rice bran constituent tricin potently inhibits cyclooxygenase enzymes and interferes with intestinal carcinogenesis in ApcMin mice.
While brown rice is a staple dietary constituent in Asia, rice consumed in the Western world is generally white, obtained from brown rice by removal of the bran. Rice bran contains the flavone tricin, which has been shown to inhibit colon cancer cell growth. We tested the hypothesis that tricin interferes with adenoma formation in the Apc(Min) mouse. Mice received tricin (0.2%) in their America...
متن کاملChemopreventive effect of fermented brown rice and rice bran (FBRA) on the inflammation-related colorectal carcinogenesis in ApcMin/+ mice.
Our previous study revealed that fermented brown rice and rice bran (FBRA) suppresses rat colorectal carcinogenesis induced by azoxymethane, the colon-specific carcinogen. In the present study, we examined the suppressive effect of FBRA on colon carcinogenesis in ApcMin/+ mouse, a mouse model for human familial adenomatous polyposis. In contrast to previous findings with the carcinogen-induced ...
متن کاملThe rice bran constituent tricin potently inhibits cyclooxygenase enzymes and interferes with intestinal carcinogenesis in Apc mice
While brown rice is a staple dietary constituent in Asia, rice consumed in the Western world is generally white, obtained from brown rice by removal of the bran. Rice bran contains the flavone tricin, which has been shown to inhibit colon cancer cell growth. We tested the hypothesis that tricin interferes with adenoma formation in the Apc mouse. Mice received tricin (0.2%) in their American Ins...
متن کاملCurrent Hypothesis for the Relationship between Dietary Rice Bran Intake, the Intestinal Microbiota and Colorectal Cancer Prevention
Globally, colorectal cancer (CRC) is the third most common form of cancer. The development of effective chemopreventive strategies to reduce CRC incidence is therefore of paramount importance. Over the past decade, research has indicated the potential of rice bran, a byproduct of rice milling, in CRC chemoprevention. This was recently suggested to be partly attributable to modification in the c...
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Agents that prevent cancer, delay its onset, or revert premalignant conditions could have dramatic beneficial impacts on human health. Although there is an urgent need to develop cancer chemopreventive agents, researchers in the field suspect that this area of scientific endeavour in Europe leads a Cinderella existence, both in terms of perception of importance and research funding. In order to...
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